Musculoskeletal side effects are the commonest cause of statin cessation. They occur much more frequently in everyday practice than in clinical trials. There is a tendency to blame all musculoskeletal problems on statins. It is essential to determine if it is really the statin that...
Dr Tim Glenie, Interventional Cardiologist at North Shore and Ascot Hospital has prepared today's content. New Oral Anticoagulants (NOACs) are used widely to prevent stroke in atrial fibrillation. Compared to warfarin, there is a lower risk of intracranial bleeding with equal, or in some studies, less...
Many of us will have over-indulged over the holiday break. Eating more healthily and losing weight are common new year resolutions. The Mediterranean diet has the best evidence base for prevention of cardiovascular disease and prolonging life. A recent study linked this diet with increased chromosomal...
Background Clopidogrel is converted to its active metabolite by a liver enzyme (cytochrome P450 2C19) Omeprazole and to a lesser extent Pantoprazole inhibit the activity of CYP450 2C19 In vitro studies show reduced levels of active Clopidogrel metabolite and less inhibition of platelet aggregation when Omeprazole and Clopidogrel...
Observational studies show a consistent relationship between low blood levels of Vitamin D and an increased risk for heart disease, cancer, diabetes and many other conditions e.g. multiple sclerosis. Randomized studies that compare patients treated with Vitamin D to those treated with placebo have been...
The Look Ahead study randomly assigned 10000 Americans to intensive dietary advice and exercise (weekly counselling for several years and less often after that) or routine advice (counselling 1 or 2 times per year). The study was stopped after 9.5 years as there was no...